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In a 40-week SUSTAIN trial, authors Frias & colleagues found semaglutide [at] 2mg was superior to 1mg in reducing A1C alongside benefits to weight management

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However, appetite changes can make it easier to overeat, especially during the first few weeks without treatment
There have been rare postmarketing reports of pulmonary aspiration in patients receiving GLP-1 receptor agonists undergoing elective surgeries or procedures requiring general anesthesia or deep sedation who had residual gastric contents despite reported adherence to preoperative fasting recommendations
