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In brief, unrelated participants were included in the GWAS analyses on the basis of European ancestry as determined by a genetic ancestry classification algorithm 36

GLP-1 receptor agonists were associated with markedly lower risks of major adverse cardiovascular events, progression of kidney disease, venous thromboembolism, and all-cause mortality compared to DPP-4 inhibitor therapy

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Changes from baseline in glycated haemoglobin (HbA 1c ), weight and other metabolic parameters were evaluated

however, it is important to recognize that many patients with HCM are currently without any identifiable pathogenic genetic etiology to their disease (40 to 60% of patients depending on the study)