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The FDA-approved criteria are designed for safety
31 As such, GLP-1 RAs and dual GLP/GIP-RAs have emerged as essential drugs for the treatment of patients with type 2 diabetes and, more recently, for the management of weight loss in the absence of diabetes
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Its architecture reflects that job: a large extracellular domain that captures one end of the peptide, joined to the seven-transmembrane core shared by all GPCRs
