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The rate of osteoporosis, a disease where the bones become fragile and brittle, was 3.2% in the group not taking the drug, compared to 4.1% in the GLP-1-taking group

Two years later, in November 2021, the FDA approved semaglutide specifically for chronic weight management under the brand name Wegovy, based on the STEP trial program

Peptides are often digested in the stomach by enzymes and are too big to be absorbed by cells in the gut

The combination kit layers amylin signaling on top, which suits research into multi-hormone metabolic crosstalk

A recent A1C test result (indicates blood sugar level over the past 23 months) Evidence of step therapy with medications like metformin