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Clinical evidence suggests tirzepatide produces greater average weight loss due to its dual-receptor mechanism, but effectiveness varies by individual

Hydrate + Move Adequate (electrolyte rich) fluids such as coconut water, herbal tea or electrolyte water

The NEJM paper documents this fall at weeks 36 and 48, while remaining above baseline
Clinical trial data show a clear hierarchy of efficacy across the three agents, though all three produce clinically meaningful results

Curr Osteoporos Rep
