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For most participants in trials, gastrointestinal symptoms were mild to moderate in severity and resolved over time

Lofton, M.D., director of the medical weight management program at NYU Langone Health and a member of HealthyWomens Womens Health Advisory Council, Some patients may find they are super responders to [the] recommended doses and can notice weight loss and other benefits when microdosing. But, theres not much research to back up the benefits of microdosing, and for that reason, professional organizations such as the American Diabetes Association do not endorse microdosing

This table illustrates the trade-off perfectly

Summary of Product Characteristics (Invokana)

Some patients may need to adjust their travel schedule or arrange for refrigerated storage through local pharmacies or medical facilities at their destination