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Current clinical evidence from a meta-analysis of phase 2 and three studies of tirzepatide in participants with T2D indicates that tirzepatide treatment is not associated with an increased risk of MACE-4, a composite outcome comprising the four outcomes cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization due to unstable angina (HR = 0.80

Abbreviations: BBR: Berberine, DBP: diastolic blood pressure, HTN: Hypertension, SBP: Systolic blood pressure

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thus, currently available data do not provide sufficient evidence to support the clinical efficacy of aducanumab