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Gastrointestinal side effects can occur with both medications, but individual response varies
The GLP1R rs6923761 variant, for example, influences GLP-1 receptor density and signaling efficiency, meaning some individuals achieve robust appetite suppression at lower semaglutide doses while others require higher doses for comparable effect
FDA approved medications are typically considered for patients with a BMI of 30 or higher
Diabetes Care 2021;44(6):13531360
