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Orlistat was associated with the greatest reduction in total cholesterol, and statistically significant results versus placebo were also obtained for phentermine plus topiramate

Taking a GLP-1 injection slightly early is generally not harmful, but doses given too close together may increase the risk of side effects such as nausea, vomiting, or abdominal discomfort

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Safety : Both drugs share similar side effects, but Tirzepatide has proven tolerability in real-world usage