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Although evidence from clinical trials has shown GLP-1 RAs to be safe and efficacious in people living with T2DM and renal impairment, their use is uncommon in this patient population

Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent renal sympathetic nerve activity that negates the diuresis and natriuresis as a negative feedback mechanism in normal rats

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In November 2025, the Trump administration announced landmark agreements with Eli Lilly and Novo Nordisk reducing the monthly price of GLP-1 weight-loss drugs from over $1,000 to as low as $245 for eligible patients