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The incretin approach for diabetes treatment: modulation of islet hormone release by GLP-1 agonism

Rather than stimulating the body to produce more growth hormone, it uses a specific fragment of GH, amino acids 177-191, that retains the fat-metabolizing properties without the growth-promoting effects

At the completion of the trial period, body weight loss regardless of dose did not reach a plateau, suggesting more weight loss is possible with longer treatment duration

The results held in studies of semaglutide or tirzepatide and across subgroups stratified by follow-up duration, population, GLP-1 agonist class, weight loss profile, GLP-1 dose, and duration

National Academies Press