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This level of weight loss is significant because even a 5% to 10% reduction in body weight can improve metabolic health, lower blood pressure, and decrease the risk of conditions like fatty liver disease and obstructive sleep apnea

These numbers assume a moderately active lifestyle

For patients with type 2 diabetes, hemoglobin A1c reductions become apparent within 12 to 16 weeks of initiating therapy

But with such a large volume of GLP-1 drugs moving through the system so quickly, the FDA may not have the time or resources to inspect in as much detail, Moore says

no jurisdiction has approved retatrutide for any indication