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Among the mechanisms, our research group and others have demonstrated that the gut microbiota fermentation (i.e., bacterial digestion of specific compounds) of specific prebiotics or other non-digestible carbohydrates is associated with the secretion of enteroendocrine peptides, such as the glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), produced by L-cells

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Toshimasa Yamauchi

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Appetite suppression makes calorie restriction almost effortless

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The approach uses advanced liposuction technology to selectively remove fat around muscle groups, revealing natural contours

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Further analysis revealed evidence of an increasing age- and sex-standardized incidence of new GLP-1 receptor agonist use during the study period, with a notable increase after 2020

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