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Smits MM, Tonneijck L, Muskiet MH, Hoekstra T, Kramer MH, Diamant M, et al

Receptor agonists are widely used in treating chronic diseases such as diabetes, asthma, neurological disorders, hormonal deficiencies, and cardiovascular conditions
The pharmacovigilance data revealed a significantly elevated incidence of adverse reactions in the metformin monotherapy cohort compared to the combination therapy group

Therapeutic effect of berberine on metabolic diseases: both pharmacological data and clinical evidence
