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GLP-1 receptor agonists demonstrate efficacy in modulating reward pathway dysfunction by normalizing insulin resistance and stabilizing glycemic variability, thereby reducing cravings and subsequently suppressing appetite [134]

They are approved for adults and pediatric patients aged 10 years and older

Furthermore, any gastrointestinal side effects can lead to fluid loss

Neurochemistry International, 138(December 2019), 104772

Study that establishes the efficacy and safety of liraglutide in patients with T2DM and moderate renal impairment, but shows a lack of effect of acute and prolonged therapy with this GLP-1R agonist on eGFR trajectory compared to placebo