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Tirzepatide 5 mg was associated with numerically lower odds and tirzepatide 10 and 15 mg were associated with numerically higher odds of experiencing nausea AEs compared with liraglutide, and all tirzepatide doses were associated with numerically higher odds of experiencing severe gastrointestinal AEs compared with liraglutide

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In our study, we found that patients with type 2 diabetes who were prescribed semaglutide or tirzepatide had various levels of risk of optic nerve and visual pathway disorders, with increased risk of NAION and other optic nerve disorders and no associations with optic neuritis, papilledema, optic atrophy, or optic disc disorders