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Combining orlistat with Wegovy represents a multi-mechanism approach to weight management, but understanding drug interactions and individual response patterns is essential before starting dual therapy

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Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist increasingly prescribed for weight loss, is generally well tolerated but may have underrecognized gastrointestinal complications

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The review considers a multi-targeting strategy, translational issues, anda future research agenda

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Methods This retrospective cross-sectional study included patients who underwent assessments of solid gastric emptying time (GET) by technetium-99m scintigraphy between May 2019 and December 2020

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