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Metformin is a preferred drug specifically for obese diabetic patients for a particular reason which is weight loss

Plasma DPP-4 activity and TG excursion were reduced, and plasma active GLP-1 was increased, in sitagliptin-treated Dpp4 +/+ mice, but sitagliptin had no effect in Dpp4 / mice (Figure 1, B and C, and Supplemental Figure 3, A and B), consistent with the selectivity of sitagliptin for DPP-4 (22)

Weeks 820: Rapid regain often 23 kg above discontinuation weight

In both groups, 56.7% of patients lost at least 5% of baseline weight

Incorporate Resistance Training: Regular strength training exercises can help maintain muscle mass and potentially slow fat pad loss