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Based on this finding, two incretin-based medications were developed: (1) DPP-4 inhibitors that increase the concentration of GLP-1 by inhibiting it [22], and (2) GLP-1RAs, which act directly on the GLP-1 receptor [23]
doi: 10.1111/jdv.12629
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Variability in response to GH therapy may also be linked to the presence of an exon-3 deletion polymorphism of the GH receptor (d3 allele), which is present in around 50% of the Caucasian population (135)
That same year, GLP-1 drug sales reached $22 billion
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