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The Phase 3 SYNCHRONIZE trials incorporate slower dose titration with the option to pause dosing during more severe symptoms, which should improve tolerability

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Orforglipron: Lillys oral GLP-1 Orforglipron showed positive results in four Phase 3 trials, Lilly said last Thursday

The FDA label includes specific guidance on dose titration schedules to minimize gastrointestinal adverse effects during initiation
