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33 The decrease in synovial DPP4 levels in RA may contribute to synovial inflammation through the SDF-1/CXCR4 axis, as the level of synovial SDF-1 was significantly correlated with inflammatory markers (serum C-reactive protein and IL-6) and disease activity score

Most physicians recommend a 1 to 2 week gap between your last semaglutide dose and your first tirzepatide dose

However, the gastrointestinal motilityinhibiting effects of GLP-1 RAs, particularly delayed gastric emptying, have raised concerns regarding pulmonary aspiration during general anesthesia or procedural sedation [3]

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TABLE 2 summarizes the potential benefits and risks of each DPP-4 inhibitor