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It increases stomach acid production, irritates the stomach lining, relaxes the lower esophageal sphincter (promoting acid reflux), and acts as a diuretic that pulls water from your body

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For the calculation of percentage of weight regain from week 36 to week 88 relative to week 36, missing weight measures at week 88 were imputed by predictions using observed data through a mixed model for repeated measures adjusted for week 0 value, week 36 value, country, sex, and maximum tolerated dose of tirzepatide at week 36

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