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Su et al., 2015) have shown that GLP-1RA treatment has a fracture risk reduction effect in patients with T2DM

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T2D presents as an aggressive disease with multiple comorbidities, and patients have a progressive failure of -cell function and progress to insulin dependence within 3-5 years post-diagnosis

Muscle is metabolically active tissue: losing it slows your resting metabolic rate, reduces strength, and makes long-term weight maintenance significantly harder

Therefore, the primary aim of this systematic review and meta-analysis is to rigorously evaluate data from available RCTs to determine the effect of GLP-1 RA therapy on key inflammatory biomarkers (CRP, IL-6, TNF-) and the oxidative stress marker (MDA) in patients with T2D