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The first is between the three "pure" GLP-1 medications
The Triple Agonists The so-called triple agonists like retatrutide hit a new hierarchy of hormone receptors: GLP-1, GIP, and glucagon to reduce appetite, control blood sugar, and increase energy expenditure

With proper nutrition, adequate protein and resistance training, this seems most likely not an issue

Gastrointestinal and Hepatobiliary Safety of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes
