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Genetic variation in GLP-1 receptor (GLP1R) and GIP receptor (GIPR) genes influences receptor sensitivity and gastric response

Across sex subgroups, effects were similar for semaglutide versus sitagliptin and for tirzepatide versus semaglutide whereas for tirzepatide versus dulaglutide, estimates suggested male patients to benefit more from tirzepatide than female patients

[DOI] [PMC free article] [PubMed] [Google Scholar] [56].Lammel S, Lim BK, Malenka RC Reward and aversion in a heterogeneous midbrain dopamine system

An intermediate dose may be considered as the maintenance dose in fragile patients, thus minimizing risks associated with GI AEs
