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Current claims are not based on placebo-controlled trials, Amiji says

Mice with mutations disrupting AMPK binding to glycogen in skeletal muscle showed increased adiposity and AMPK instability, where glycogen binding is essential for AMPK stability and energy homeostasis [98]

I., Begum, K., Hussain, A., Iqbal, J., Aufreiter, S., Beggs, M

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The economic burden is considerable: annual direct healthcare costs attributable to MASLD in the United States and Europe are estimated in the tens of billions of dollars, driven by hospitalizations, liver-related procedures, and management of comorbid conditions [6]