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In clinical trials, more people stopped taking Mounjaro due to gastrointestinal side effects, and both medications had more side effects at higher doses

However, the GLP-1R is also involved in adipogenesis in the periphery, which may account for this discrepancy (Challa et al., Glp1r/ mice, animals with deletion of the GLP-1R in vagal afferent/efferent nerves, Phox2b-Cre Glp1r flox/flox , as well as animals with a deletion of the GLP-1R in the CNS, nestin- Cre Glp1r flox/flox , maintain a similar body weight and food intake as control mice on both chow and HFD (Sisley et al., 2014)

Impact of glucagon-like peptide-1 receptor agonists on adiponectin concentrations: A meta-analysis of randomized controlled trials

Nat Commun 15 , 5912 (2024)

Signs of a severe allergic reaction include swelling of your face, lips, tongue, or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, and very rapid heartbeat