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Likewise, the PCE of retatrutide were blocked by 1 M (-)-N 6 -phenylisopropyladenosine (PIA), an A 1 -adenosine receptor agonist, and this effect was reversed by 1 M DPCPX, an adenosine A 1 -receptor antagonist

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Combined therapy can produce insomnia, anxiety, tremor, and elevated heart rate (from phentermine) plus nausea, constipation, and vomiting (from semaglutide)
She outlined several critical areas where physicians and health systems should focus their risk mitigation efforts
