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Ideal candidates are: Adults with a BMI 30 (or 27 with weight-related conditions like diabetes/hypertension) Those committed to lifestyle changes (diet/exercise) Without history of heart disease, uncontrolled hypertension, or substance abuse Note: Requires prescription and medical supervision

doi: 10.2174/1381612825666190206105232 [DOI] [PubMed] [Google Scholar] 13.Scheen AJ

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We systematically characterized different combinations of constitutive promoters driving MTNR1A expression and synthetic promoters driving transgene expression, achieving either tight regulation of transgene expression or a balance of high expression and low leakiness, thereby making it possible to tailor system performance for specific applications