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The method includes the steps that an Oct-gamma-Glu(tBu)-AEEA-AEEA-OH side chain fragment and a Fmoc-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(tBu)-Val-OH hexapeptide fragment are prepared in advance, and then the two fragments are coupled to a semaglutide main chain sequence to obtain the semaglutide

Translocation of Notch1s inner cellular domain into the nucleus subsequently activates the transcription of Hes1

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Semaglutide is a medication that belongs to a group of drugs called GLP-1 receptor agonists

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