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Description
Supply shortages The global semaglutide shortage that began in 2022 and persisted through much of 2024 pushed many people toward alternative sources

Many trials used 7 to 15 grams per day with positive effects on satiety and small but significant weight reductions

Gen Comp Endocrinol 175, 2733, doi: 10.1016/j.ygcen.2011.11.025 (2012)

Based on findings from the FLOW trial, recent guidelines have elevated GLP-1 receptor agonists to the same level of recommendation as SGLT2 inhibitors for people with CKD [84]

While originally developed for diabetes, semaglutide and tirzepatide are FDA-approved for weight loss in adults with or without diabetes
