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For example, in head-to-head trials, patients on the highest dose of Zepbound lost up to 22.5% of their body weight over 72 weeks, while those taking semaglutide GLP-1 (Wegovy) lost about 15% over a similar period

Chronic activation of microglia is associated with protein degradation, mitochondria dysfunction, and defects of axonal transport and apoptosis, which adversely affect neuronal function and lead to cell death (49)

In both cases, there are important compliance and PBM contractual considerations that need to be explored and fully vetted as part of decision making

It can completely derail your progress and force you to restart your titration schedule