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Multivariate analysis of fasting glucose showed that fasting glucose was lower in the placebo arm at 12 months (2.2 mmol/L 95%CI: 0.4, 4.1, p = 0.027) but not at 6 months (1.4 mmol/L, 95%CI 1.1, 3.9, p = 0.24) (Supplementary Tables 10.1 and 10.2)

GLP-1RAs are being studied for their significant associations with reduced risks of various cardiovascular diseases, neuropsychiatric or substance use disorders, infectious illnesses and respiratory conditions, indicating their potential for broader therapeutic applications [111]

GLP-1 receptor agonists do not directly interfere with anaesthetic drugs themselves there is no known pharmacological interaction that affects how anaesthetic agents work or are metabolised, as confirmed in the Summary of Product Characteristics (SmPC) for these medications

November 2025: FDA approved expanded Zepbound (tirzepatide) indication for moderate-to-severe obstructive sleep apnea in adults with obesity, following SURMOUNT-OSA trial data showing 62.8% reduction in apnea-hypopnea index the first drug approval for sleep apnea treatment

Lets walk through the details of sleeping on semaglutide and, more importantly, what to do if youre taking the medication and struggling to get some shut-eye