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The main difference between the two lies in the active ingredient

Triple-receptor agonist, GLP-1, GIP, and glucagon pathways Extended half-life for stable pharmacokinetic profiles Subject of multiple ongoing clinical trials Pre-filled pen for precise, repeatable delivery Janoshik-verified, 99% purity guaranteed What Researchers Say Frequently Asked Questions Retatrutide (LY3437943) is an investigational triple-receptor agonist targeting GIP, GLP-1, and glucagon receptors

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10.1007/s00125-017-4450-9 Diabetologia 85 KahlesF.MeyerC.MollmannJ.DieboldS.FindeisenH

This phase 2 trial suggested semaglutide was safe in patients with LVO and was associated with an improved neurological outcome in patients not receiving IVT