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Am J Public Health

The FDA-approved oral Wegovy (semaglutide 25 mg) is currently the only safe, proven oral GLP-1 for weight management

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Semaglutide A few RCTs evaluated semaglutide in PCOS, all at high risk of bias due to small sample size and selective outcome reporting

The peptide sequence incorporates aminoisobutyric acid (Aib) residues at positions 2 and 13, which contribute to albumin binding affinity and extended circulating half-life
