metsera glp 1 Pfizer Acquisition and GLP-1 Obesity Drug Market S-1/A

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For instance, experiments involving the co-incubation of Caco2-cells with Enterococcus faecalis or Mitsuokella multiacidus bacterial supernatants have shown a significant decrease in GLP-1 mRNA abundance 73

It increases the risk of type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver, and obstructive sleep apnea 3-11-fold

These side effects are generally manageable and can be minimized by starting with a lower dose and gradually increasing it as tolerated

59 Recently, the SURMOUNT-5 trial demonstrated that tirzepatide was superior to semaglutide in obese patients without diabetes with respect to reductions in body weight and waist circumference at week 72