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and helps reduce fat accumulation

109 In addition, GLP-1RAs have the same efficacy as TZDs when combined with metformin for menstrual recovery 117 (Table 1)

Many patients also experience bloating, excessive gas (flatulence & belching), and heartburn

The timing depends on the FDA's rigorous review process of the clinical trial data on retatrutide once it is submitted, however, it is unlikely to be approved and available until at least late 2026 and possibly into 2027 or 2028

22,23 Bariatric surgery is another option for inducing weight loss in obese individuals if the aforementioned treatment strategies fail, although patients often develop post-surgery complications requiring further therapeutic intervention