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The study, led by UCSF neuroscientist Khaled Moussawi, M.D., Ph.D., looked at rats, which share remarkably similar brain-reward circuits as humans

Relative to metformin, liraglutide plus metformin and semaglutide plus metformin showed very high posterior probabilities of achieving more than 1.0 kg additional weight loss, while liraglutide monotherapy and exenatide plus metformin also showed high posterior probabilities of clinically meaningful benefit

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However, long-term use is likely necessary, as stopping the medication often leads to weight regain