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doi: 10.1016/j.molmet.2017.06.007
doi: 10.1037/hea0000207 61 ForsytheP.SudoN.DinanT.TaylorV
Low blood sugar is more likely when Janumet XR is used with insulin or an insulin secretagogue such as a sulfonylurea
Pharmacologically, signaling studies demonstrate that tirzepatide mimics the actions of native GIP at the GIP receptor but shows bias at the GLP-1 receptor to favor cAMP generation over -arrestin recruitment, coincident with a weaker ability to drive GLP-1 receptor internalization compared with GLP-1
