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Figure 1: Landscape of GLP-1 coverage in Medicaid for weight loss indication "Recent change" is relative to KFFs August 2024 report

Overall, the effect of GLP-1RAs on muscle mass shows a high degree of heterogeneity in clinical trials: some studies report that lean body mass reduction accounts for 40% to 60% of total weight loss, while others indicate that the proportion of lean body mass reduction is approximately 15% or lower [50]

[1] [2] You should also schedule a routine review if gastrointestinal side effects persist beyond 46 weeks without improvement, as this may indicate the need for dose adjustment, additional symptomatic management, or consideration of alternative weight management strategies