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Overall, these findings emphasize that while AAS is rare in PsA, it appears to be linked to structural damage and axial involvement, rather than to current inflammatory activity alone

While pancreatic -cells are the principal therapeutic target, GLP-1Rs are widely expressed in -cells, exocrine pancreas, intestinal mucosa, renal tubules, pulmonary epithelium, selected brain nuclei, and the cardiac sinoatrial node

Extended abuse can lead to the development of mental health disorders

Some patients adapt well once they see the pattern

This article examines what the science and UK clinical guidance actually say about B12 supplementation and weight loss, identifies who genuinely needs B12 supplementation, outlines safe dosage according to NHS and BNF recommendations, and sets out the evidence-based weight management strategies endorsed by NICE