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Summary: Metformin typically produces modest weight loss of 13 kg, whilst Rybelsus (oral semaglutide) demonstrates more substantial reductions of approximately 35 kg over 612 months in patients with type 2 diabetes

The study did not include GLP-1 patients specifically, but the mechanism of RF (controlled dermal heating triggering fibroblast collagen synthesis) is exactly what GLP-1 patients with proposed cellular mechanism effects would need to support skin quality

Clinical criteria typically include a documented BMI of 30 or higher, or 27 or higher with a related comorbidity

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.AstraZeneca

Eris Lifesciences, which has a partnership with Natco to sell generic semaglutide, said its brand Sundae will be offered at the same price for the starting dose