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It has been suggested that in obese patients, these adipokines act peripherally, causing lipid accumulation, lipotoxicity, endoplasmic reticulum stress, mitochondrial dysfunction, and ultimately, cell apoptosis [111,112,113]

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Diabetologia 65(1):1436 Gregg EW, Chen H, Wagenknecht LE et al (2012) Association of an intensive lifestyle intervention with remission of type 2 diabetes

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"I think the pills can make a difference, but they have to first be approved for use on the NHS and we then need services with the right teams to be able to manage their use in patients