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Molecular Mechanisms behind Obesity and Their Potential Exploitation in Current and Future Therapy

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Introduction People with type 2 diabetes are prone to developing hyperkalemia, especially those with comorbid conditions such as heart failure and chronic kidney disease.123 However, several drugs that improve clinical outcomes in people with type 2 diabetes and related comorbidities increase serum potassium levels, such as inhibitors of the renin-angiotensin-aldosterone system.456789 Hyperkalemia is associated with a risk of life threatening cardiac arrhythmias and increased mortality,10 and the occurrence of hyperkalemia frequently leads to dose reduction or discontinuation of cardiorenal protective drugs