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15,392 In Wistar rats, a diet high in fat was found to lead to a decrease in the ratio of OPG/RANKL, which resulted in increased bone resorption and ultimately a reduction in bone mass

Similar to GLP-1 RAs, the majority of DPP-4 inhibitor AE reports originated from the US (57.71%)

Indeed, peripheral insulin levels are ~2-fold higher in patients with T1D compared to patients matched for hyperglycemia (33)

These approaches may not offer the rapid results of a GLP-1, but they lay a powerful foundation for long-term health and vitality
doi: 10.1016/j.molmet.2019.11.018