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A 2025 meta-analysis found that semaglutide increased the relative risk of cholelithiasis (gallstones) by 1.92 , liraglutide by 1.75 , and tirzepatide by 1.36

Includes medication, supplies, and medical supervision

If sexual dysfunction is going to be a significant issue, this is usually when it becomes apparent and concerning

Semaglutide May Be Ideal If You: Prefer a more established, widely available option Are beginning your medical weight loss journey Want to test GLP-1 therapy before considering dual-action drugs Have moderate weight-related health concerns Tirzepatide May Be Ideal If You: Are struggling with more resistant weight Want the most advanced option available for fat reduction Have pre-diabetes, insulin resistance, or other metabolic concerns Did not see optimal results with GLP-1 therapy alone Safety and Side Effects Both medications are well-tolerated by most patients, though they can cause side effects such as: Nausea Fatigue Constipation or Diarrhea Mild injection site irritation The risk and intensity of side effects tend to be dose-dependent and usually subside as your body adjusts

Serious side effects warrant immediate medical attention