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As part of the incretin hormones, GLP-1 has three known mechanisms of action: activating glucose-dependent insulin secretions, thereby reducing plasma glucose, suppressing glucagon secretion, and delaying gastric emptying [3]

5 Therefore, whether it can cross the BBB determines the effect of the drug

In another study, a double-blind, parallel-group design was employed to investigate the impact of semaglutide on gastric emptying in 72 adults diagnosed with obesity