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36, 23462350 (2013b)
GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning through Hypothalamic AMPK
Research shows that GLP-1 medications paired with growth hormone-releasing peptides like Sermorelin can help preserve muscle mass during weight loss
The numbers reported on 21 May 2026: 4 mg dose: 17.6% average body weight loss at 80 weeks 9 mg dose: 23.7% average body weight loss at 80 weeks 12 mg dose: 25.0% average body weight loss at 80 weeks rising to 28.3% on the efficacy estimand Placebo: 3.9% average body weight loss at 80 weeks And then the extension cohort 532 participants with starting BMI 35, escalated to their maximum tolerated dose for another 24 weeks lost an average of 30.3% of their body weight at 104 weeks
Zinman B, Gerich J, Buse JB, et al
