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90 However, the main drawbacks of TZDs are that they cause weight gain (particularly subcutaneous adiposity), they may increase ones risk of bladder cancer, 91 and they may worsen congestive heart failure, though they are not associated with increased mortality

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Webster et al 15 analyzed data from patients in controlled clinical trials who achieved a clinicians rating of clear and compared it to that from patients who were rated almost clear. In these trials, a total of 1,366 subjects were treated with ivermectin, metronidazole, or vehicle

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