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Despite the lack of extra support for lifestyle modification as part of the SURPASS program, 4069% of patients achieved 10% weight loss with the highest doses of tirzepatide (1015 mg), which ranged from 9.5 kg to 12.9 kg [100]

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Numerous reports also emphasize the neuroprotective role of GLP-1 mediated signaling, as it was proven to protect synapses, improve synaptic functions, enhance neurogenesis, protect neurons from oxidative stress, and reduce neuronal apoptosis

Identification of a regulatory pathway of l-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells